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Interview with Dr. Johannes Coy

15 Answers to the Gene TKTL1

When Johannes Coy discovered the TKTL1 gene, it was clear only to him that he was on to something big. Initially declared a defective gene, TKTL1 received little attention in research for many years. But in 2022, it became a key part of the work for which Svante Pääbo was awarded the Nobel Prize. However, the groundbreaking findings about the role of TKTL1 in human brain development are far from all there is to learn about this gene. Via his re-interpretation of the Warburg effect, Coy finds that fermentation metabolism controlled by TKTL1 both protects healthy cells and allows cancer cells to survive and spread. In the interview, Coy answers 15 questions about TKTL1 and shares a lot of personal information about his journey as a scientist and discoverer of this pivotal gene.

15 Answers to the Gene TKTL1

When Johannes Coy discovered the TKTL1 gene, it was clear only to him that he was on to something big. Initially declared a defective gene, TKTL1 received little attention in research for many years. But in 2022, it became a key part of the work for which Svante Pääbo was awarded the Nobel Prize. However, the groundbreaking findings about the role of TKTL1 in human brain development are far from all there is to learn about this gene. Via his re-interpretation of the Warburg effect, Coy finds that fermentation metabolism controlled by TKTL1 both protects healthy cells and allows cancer cells to survive and spread. In the interview, Coy answers 15 questions about TKTL1 and shares a lot of personal information about his journey as a scientist and discoverer of this pivotal gene.